Predictive factors of facial nerve function after medium/large vestibular schwannoma surgery: relationships between time of surgery, dimensions and size of resection

Abstract

Background

Vestibular schwannomas (VS) are slowly growing tumor, deriving from the vestibular component of cranial nerve VIII. Primary treatment modalities include microsurgery, radiosurgery, a combination of microsurgery and radiosurgery, and conservative treatment. The management of VS is a matter of debate, particularly in case of small tumors (less than 2 cm in diameter size).

Methods

We performed an institutional retrospective review of a consecutive series of 28 surgically treated patients suffering from VS, operated in our institution. Patients were assigned on the ground of the preoperative imaging in two groups: tumors with major diameter of extra-meatal portion measuring ≥ 3 cm (Group I, 16 patients) and tumors with major diameter < to 3 cm (Group II, 12 patients).

Results

The total amount of 18/28 patients were females; the average age was 60.1 years. The average duration of the preoperative symptoms was 25.2 months, while the average interval between the diagnosis and surgical treatment was 8.68 months. The average preoperative volume was, respectively, for Group I and II tumors of 14.35 cm³ and 3.73 cm³. Age was associated to the duration of the preoperative symptoms (r = − 364; p = 0.044), with the probability to develop a complication (p = 0.031) and preoperative low HB score (r = − 324; p = 0.040). The presence of hypoacusis as preoperative symptom was strongly associated to a lesser postoperative maximum diameter and smaller residual disease (p = 0.014). Group I had a significantly longer hospitalization period in respect to Group II (p = 0.001) that impacted negatively to postoperative performance status (r = 0.368, p = 0.042).

Conclusions

We confirmed the strong association between age and size of the lesion and the clinical results, where larger lesions in older patients are more prone to complications than smaller in young patients. We found that the patients presenting hypoacusis at onset were associate to lesser preoperative FN impairment outlining a possible differential involvement of the CN related to the internal meatus. We also introduce the strong association of Koos grade with postoperative performance status, hospitalization and facial nerve functionality.

Introduction

Background

Vestibular schwannomas (VS) are slowly growing, indolent tumors, deriving from the vestibular component of cranial nerve VIII [1]. Primary treatment modalities include microsurgery, radiosurgery and a combination of the two [2,3,4].

By larger VSs, the patient’s quality of life (QoL) can be seriously compromised because of major neurological impairments. Surgery remains the milestone in the management of these tumors, especially where the maximum diameter is over 20 mm, the lesion seriously compresses and possibly dislocates the brainstem (BS) or is cause of severe vestibular symptoms [1, 5,6,7]. Nowadays, in the western countries, thanks to the increased diagnostic means, early detection of VS from systematic request for an magnetic resonance imaging (MRI) by hearing loss and/or tinnitus, the number of tumors detected per year has dramatically increased [3, 8,9,10], and, simultaneously with the mean tumor size steadily decreasing, the optimal management of VS remains a matter of debate, in case of asymptomatic small tumors smaller than 2 cm in diameter size [10], but also in case of oligosymptomatic medium tumors (Grade of Koos 2—from 2 to 3 cm in diameter) [11]. The larger and symptomatic tumors are generally considered for microsurgical excision except in patients suffering from significant comorbidities possibly complicating open surgery [2,3,4, 8,9,10,11]. Because of the debated emergent evidence of efficacy of the radiosurgical treatments, even for larger lesions [4, 9, 10, 12], the optimal management of the medium- and small-sized tumors remains either still unclear and still controversial, especially considering the reported, and probably not completely understood, long-term side effects of the radiation treatment [2, 10]

Purpose of the investigation

In this study, we reviewed a retrospective series of patients suffering from VS, divided in two subgroups according to preoperative diameter of lesion, whose facial nerve (FN) function was evaluated pre- and postoperatively, along with an analysis of the complication rate and functional status changes, in the context of a retrospective single-center single-operator consecutive series of patients.

Patients and methods

Participants and Eligibility

We performed an Institutional retrospective review of a consecutive series of surgically treated patients suffering from VS (Fig. 1), operated on in the Department of Neurosurgery of Policlinico Umberto I of Rome (Università “La Sapienza”) by the Chairman of the Institution and senior author (AS). We collected a total of 28 patients. Histological diagnoses were performed according to the updated version of the WHO guidelines [13]. The patients who were enrolled in the final cohort in the period ranging between January 2013 and December 2017 met the following inclusion criteria:

• 1. Younger than 75 years old patients,

• 2. Whose clinical, surgical and radiological records concerning their VS were complete and available for consultation

• 3. Suffering from no further intracranial or spinal neoplastic, infectious, vascular or inflammatory condition, in order to avoid jeopardization of the functional and neurological results

• 4. Who did not undergo a previous stereotactic radiosurgery (SRS) or other radiation treatments

Fig. 1

A typical VS MRI

All the patients who met the aforementioned inclusion criteria were assigned on the ground of the preoperative imaging to the following subgroups:

Tumors classified as Group I: the major diameter of extra-meatal portion measure ≥ 3 cm, grade III of Koos grading (KG) classifications (mentioned in Table 1 as KG3, 16 patients).

Table 1 Patient’s demographics

Tumors classified as Group II: the major diameter of extra-meatal portion measure < to 3 cm, grade II of Koos classifications (mentioned in Table 1 as 2, 12 patients).

Patients were preoperatively offered of all the treatment options, including conservative management and SRS, and the surgical indication was confirmed, for each patient, according to the following factors:

• 1. Age

• 2. Personal preference of the patient,

• 3. A preoperative feasible plan for a satisfactory decompression of the compressed nervous structures

• 4. Neurological symptoms related to the mass, including BS and cranial nerves (CNs) compression,

• 5. Lesion related dilation of the supratentorial ventricle system

• 6. For oligo-asymptomatic patients, evidence of significant growth while the patient was included in the follow-up program of our institution.

• 7. For patients with preserved functional hearing, a durable hearing preservation was the target and therefore played a role in deciding for surgical resection either [11].

For all the included patients, we recorded age, sex, clinical onset (specifically with the first and second presenting symptom—in order of appearance—and the presence/absence of a cochlear, vestibular or facial nerve at the clinical onset), hospitalization length, interval between diagnosis and surgery and preoperative duration of the symptoms.

The FN function was clinically evaluated pre- and postoperatively by means of the standard version of the House–Brackmann scale, extensively validated in the relevant literature [9, 14,15,16]. Vestibular and cochlear dysfunctions were preoperative evaluated, by means of a dichotomous variable (0/1−No/Yes) whenever a clinical history or a diagnostically proven presence of vertigo and/or tinnitus/hypoacusis/anacusis was preoperatively reported.

The extent of the lesion was recorded as follows:

• 1. Preoperative and postoperative volume of the contrast-enhancing lesion was calculated drawing a region of interest (ROI) in a volumetric enhancing postcontrast study weighted in T1 (a multi-voxel study), conforming to the margins of the contrast-enhancing lesion with software Horos [17].

• 2. Maximum preoperative and postoperative diameter of the lesion, as measured in slice in which the diameter appeared to the wider in the gadolinium-enhanced T1-weighted pre- and postoperative MRI study.

A focus was on the KPS results as an index of the functional status of the patients: Such parameter was considered, as previously observed demonstrative of QoL [10, 18]. In particular it was recorded in two different moments: 1. before surgery, 2. at 30 day after surgery.

Radiological and surgical protocols

All the patients included underwent a preoperative brain MRI scan, following our institutional protocol, included an high field 3 Tesla volumetric study with the following sequences: T2w, FLAIR, isotropic volumetric T1-weighted magnetization-prepared rapid acquisition gradient echo (MPRAGE) before and after intravenous administration of paramagnetic contrast agent; a constructive interference steady state (CISS) completed the protocol for what concerns the cerebellum pontine angle (CPA).

All the procedures were performed with an infrared-based neuronavigator (Brainlab, Kick® Purely Navigation), in a standard neurosurgical theater, with a standard operative microscope (Leica, model OH4). A standard total intravenous anesthesia protocol has been used. Because of the routinely employed intraoperative neuromonitoring realized with use of stimulating probes in order to “map” the course of the VII CN, no muscle relaxants were administered.

Surgery was in all cases performed through the retrosigmoid approach (RSA) by the senior author (A.S.). The target was a satisfactory resection (GTR/NTR), with decompression of the impaired nervous structures and preservation of both the facial and the cochlear nerve functions, regardless of preoperative hearing status or preoperative facial nerve impairment. All patients were operated in the lateral park-bench position. The FN was monitored by intermittent electrical stimulation of the intracranial FN with the NIM nerve monitoring system (Medtronic Inc., Minneapolis, MN, USA) as well as free facial electromyography (EMG). We also used somatosensory evoked potential monitoring for all patients. Lower cranial nerves were also routinely monitored. Details of the RSA for VS removal have been extensively discussed in the neurosurgical literature. In general, it was intraoperatively judged mandatory to stop tumor excision when the IoN outlined an unquestionable risk for permanent postoperative facial nerve morbidity.

Evaluation of the extent of resection

The extent of resection (EOR) was determined through a comparison between the MR images obtained before surgery and the MRI performed 30 days after surgery. EOR was calculated as a percentage by comparing the preoperative and early postoperative imaging, with the aforementioned software. GTR was defined as a confirmed reduction of the preoperative volume of the tumor of at least 95%; conversely, a near-total resection or subtotal resection was a surgical result of, respectively, a 90–95% and less than 90% resection rate (NTR and STR, respectively).

Follow-up program

A close range dedicated clinical and neuroimaging follow-up program was routinely performed in our institution. This program included:

• 1. A standard early (maximum 24 h after surgery) postoperative brain CT scan to rule out major and eventually clinically silent complications [19].

• 2. At approximately one month after surgery (25–35 days), a volumetric brain MRI scan was repeated for a first step follow-up control. When a slowly growing grade I lesion was histologically confirmed, in case of NTR/STR brain MRI scan repeated at three months, whereas in case of GTR it was postoperatively repeated directly at six months after surgery.

For every radiological reevaluation, we performed a complete outpatient clinical and neurological reevaluation. Generally, during this reevaluation, the functional status (as expressed with KPS scores), the neurological conditions in regard to the facial, cochlear and vestibular nerve were accurately recorded. The overall condition of each patient, according to his/her perception of the life, was also recorded, and coded in three-step ordinal variable as 0. worsened, 1. stable and 2. improved. A special focus was also paid on the surgery-related complications experienced by the patients. In particular we recorded the incidence of postoperative hydrocephalus, hematomas, CSF leaks, infections and meningitis.

Statistical methods

The sample was analyzed with SPSS version 18. Comparison between nominal variables have been made with Chi² test. Continuous variables’ means were compared with one-way, repeated measures, multivariate ANOVA analysis along with contrast analysis and post hoc tests and investigated with Pearson’s bivariate correlation. Threshold of statistical significance was considered p < 0.05.

Potential source of bias and study size

A potential source of bias is expected from exiguity of the sample, which, in regard to the endpoints selected, presents an fair post hoc statistical estimated power (1 − β = 0.76 for age groups and complications incidence, 1 − β = 0.71 and 1 − β = 0.75, respectively, for EOR and status for α 0.05 and effect size 0.8), thus providing reliable conclusions for strong statistical effects.

The study is a historical cohort study (retrospective purely observational, non-sponsored): Outcome and exposure of the patients occurred and consolidated before the start of the study and there is no ethical problem requiring approval of the ethical committee. Before surgical procedure, all the patients gave informed written explicit consent after appropriate information. Data reported in the study have been completely anonymized. No treatment randomization has been performed. This study is consistent with Helsinki declaration of human rights of research.

Results

In a first step, we retrospectively reviewed the clinical, radiological and surgical records of 28 patients operated on by a RSA for the resection of VSs in the period ranging between 2013 and 2017. The total amount of 18/28 patients were females; the average age was 60.1 years ± 13.99. The average duration of the preoperative symptoms was 25.2 months ± 23.4, while the average interval between the diagnosis and surgical treatment was 8.68 months ± 7.97. Preoperatively all the patients included had, respectively, a HB score < 2 and a KPS > 80% in 100% of cases. The average preoperative volume was, respectively, for Group I and II tumors of 14.35 cm³ ± 7.97 and 3.73 cm³ ± 1.46 (Table 1).

The most common presenting symptoms were hearing involvement or loss with a total of 19/28 patients suffering from tinnitus, hypoacusis or cophosis, followed by a total of 11 patients presenting with vertigo (respectively, 67.8% and 39.2%). A total of 13/16 and 11/12 patients belonging to Group I and Group II, respectively, were stable or improved after surgery in regard to KPS (81.25% vs. 91.66%), while a total of 10/16 and 4/12 patients belonging to Group I and Group II, respectively, had a postoperative HB score > 3 after surgery (62.50% vs. 33.33%). The achieved EOR was overcrossing 95% in 78.57% of cases (22/28 patients).

A total of 10/16 and 3/12 patients belonging to Group I and Group II experienced a postoperative complication (62.5% vs. 25.0% p = 0.055—Fig. 2). Three out of the 10 complications of Group I and 1 of the 12 of Group II proved to be stable complications (18.75% vs. 8.33%). In details, fifteen patients postoperative course was uncomplicated, the remaining experienced in 10 cases a transient hydrocephalus, which was in three cases treated with a EVD until resolution of the postoperative edema; in two cases a CSF cutaneous leak which caused a wound problem; in one case the course was extremely benign with a significant tendency to spontaneous resolution; in the remaining case it was necessary to admit the patient in the division to position a 4-day long active lumbar drainage, until complete resolution of the complication. We recorded one case of postoperative FCP postoperative hematoma, a patient who after a period of ICU hospitalization died of pneumonia. The overall mortality rate is 3.57%. No deficit of the lower CN was recorded.

Fig. 2

Chi² bar charts disclosing the incidence of complication in KG 2 and KG 3 subgroups

Age

Age was statistically associated to the duration of the preoperative symptoms (r = − 364; p = 0.044), with the probability to develop a complication (p = 0.031) and also with the preoperative HB score (r = − 324; p = 0.040); the elderly, with a longer preoperative duration of symptoms, are a fragile subgroups of patients.

Hypoacusis

The presence of hypoacusis as preoperative symptom was strongly associated to a lesser postoperative maximum diameter and therefore with a smaller residual disease (p = 0.014—Fig. 3). Moreover, patients presenting hypoacusis at onset were associate to lesser preoperative FN impairment (p = 0.018—Fig. 4), thus outlining a possible differential involvement of the CN related to the internal meatus.

Fig. 3

Box plot describing the correlation between hypoacusis at onset and postoperative diameter of the lesion

Fig. 4

ANOVA bar chart describing the association between the preoperative HB score and hypoacusis at onset

Classification of Koos: House–Brackmann, KPS and postoperative complications

HB and KPS showed a strong reciprocal statistical association, both in regard to the pre- and postoperative period outlining that the better preoperative function predicts the better postoperative outcome. Most importantly, the both outcome variables are strongly associated to the personal perception of the QoL of the patient, 30 days after surgery (r = 0.725 p = 0.001), thus highlighting the extreme psychological impact of the FN on the QoL as it is experienced by the patients.

Koos grade 2 or 3 lesion disclosed no significant preoperative KPS and HB scores difference, whereas in the postoperative period, a strong trend toward worse HB outcomes was retrieved in patients suffering from Koos grade 3 lesions (p = 0.069—Fig. 5). Moreover, KG 3 lesion had a significantly longer hospitalization period in respect to the KG 2 counterparts (p = 0.001—Fig. 6) and the longer hospitalization was negatively related, as expected, to postoperative KPS (r = 0.368, p = 0.042).

Fig. 5

Chi² bar charts disclosing the postoperative HB scores in KG 2 and KG 3 subgroups

Fig. 6

ANOVA bar charts disclosing the different average length of hospitalization in KG 2 and KG 3 subgroups

As already introduced, KG 3 lesions disclosed a trend toward a statistical association with complications in respect to KG 2 lesions (p = 0.055) and thus with outcomes, with a rate of KPS score > 80% of 81.25% versus 91.66% of patients. The incidence of postoperative complications, as a dichotomous variable (1/0 Yes/No), demonstrated a strong association with the postoperative KPS (p = 0.010), the length of hospitalization (p = 0.011, Fig. 7) and interestingly with the preoperative volume of the lesion (p = 0.030, Fig. 8).

Fig. 7

ANOVA bar chart describing the association of the postoperative KPS and the incidence of complications

Fig. 8

ANOVA bar charts describing the association between the preoperative volume of the lesion and the incidence of complications

Discussion

VS is the most common cerebellopontine angle (CPA) tumor, representing up to 75% of skull base tumors [1]. Several different management approaches were previously advocated, including radiotherapy, observation and periodic control of the tumor, and of course surgery. The “wait and see” option may be suitable under certain circumstances, such as patients in advanced age groups, in poor general health conditions, with small tumors, few or no symptoms or with relatively well preserved hearing [7] but also when the tumor causes no other symptoms, than an auditory function impairment. Because of the increased precocity of the diagnosis, and because, at the diagnosis, patients are extensively informed about the slow growth of the tumor and they suffer, at the beginning, from minimal disturbances, it is increasingly frequent to find patients who prefer to undergo an observation program until the tumor manifests with more significant neurological disturbances (related to the greater tumor sizes), although a greater size of the tumor itself works as a predictor and risk factor for major complications and postoperative facial nerve impairment [1,2,3,4,5].

About the natural history of the conservatively managed VS an overall slow growth rate ranging from 0.66 to 0.78 mm/year has already been reported [5]. Deen et al. [5] analyzed a cohort of patients suffering from conservatively managed VS, and found that none of these patients had spontaneous shrinkage of tumor, rather most continued growing, eventually requiring surgical management. Nakatomi et al. [6] reported that patients with STR would have tumor recurrence at an average of 2.7 years postoperatively.

Although complete removal of the tumor is still to be considered the gold standard, many studies with complete surgical resection of large VS have reported high rates of facial nerve dysfunction (31–57%). For this reason, there is a trend toward STR of the tumor with planned postoperative SRS [4, 8] which, unfortunately, SRS bares its own inherent risks, including tumor swelling and facial neuropathy [3, 9]. Postoperative management of patients with STR depends on the amount of residual tumor and the rate of tumor growth. The goal of our surgery was GTR with preservation of both the facial and the cochlear nerves, regardless of preoperative hearing status.

A surgically induced FN injury is the most common complication of VS surgery. Facial nerve function is considered satisfactory as long as the House–Brackmann grade is 3 or less. The review of 89 articles on facial nerve function reported 78% of preservation with the RSA in tumor size of < 20 mm and 67% in larger tumors [18]. Postoperative facial function is one of the main priorities of VS surgery.

Consistently, the intraoperative facial neuromonitoring has become unavoidable; it enables the nerve integrity to be preserved in the majority of patients [20, 21]. In any case, the preservation of acceptable FN function after surgery is the key concern for most patients with VS.

With the adoption of a functional sparing surgery policy, the functional results on the FN improved considerably, at the price of less radical resections, with a subsequent increased risk of tumor regrowth. Some investigators advocate planned partial resections to minimize the risk for the cranial nerves, leaving significant postoperative tumor residues [9, 16]. Others assert that good postoperative FN outcomes do not depend on the extent of resection if the resection is carried out with a priority given to FN preservation [9, 16, 22]. A negative association between the postoperative clinical results and the size of the tumors has been advocated by several investigators, although in relatively wide surgical series and never unquestionably demonstrated [12, 14, 23]. In general, tumors under 20 mm of diameter, with an outcome of V and VI HB grade, were observed in a low percentage of patients, while the incidence of such results increased notably when the tumor was above this size.

In VS surgery, the adhesion between tumor and facial nerve determines a greater intraoperative manipulation [20]. Dissection of the facial nerve tumor capsule may produce a contusive effect on the nerve fiber thus disrupting the local microcirculation, leading to a transient ischemia leading to a degeneration of the nerve fibers. Such a cascade of events could explain the worsening of the postoperative FN function. For this reason, several authors outlined that the two main anatomical factors determining the possibility to spare the FN are the tumor adhesion or encasement of the FN itself, and the larger size of the tumor [23, 24]. This finding proved to be independent from surgical approach employed, disclosing that for lesions under 30 mm of diameter, the incidence of poor FN outcomes was low, regardless of the surgical approach used.

Our experience confirms the aforementioned findings. In our series, smaller lesions were associated to better clinical outcomes, lesser incidence of complications and shorter hospitalization periods. Therefore, we advocate a timely surgical treatment, either for large lesions determining a significant neurological impairment at diagnosis, and for relatively small VS (KG 2) lesions, in oligo-asymptomatic patients, whose tumors demonstrated an ascertained growth tendency in a radiological follow-up program. The increasing evidence of a negative association between the size of the lesion and the clinical results should always be, in our opinion, an essential part of the preoperative patient information.

Conclusions

Preservation of FN function during resection of vestibular schwannomas (VS) remains one of the key targets to preserve the QoL of the patients. In this study, we confirmed the strong association between age and size of the lesion and the clinical results, where larger lesions in older patients are more prone to complications than smaller in young patients. We found that the patients presenting hypoacusis at onset were associate to lesser preoperative FN impairment outlining a possible differential involvement of the CN related to the internal meatus. We also introduce the strong association of KG with postoperative performance status, hospitalization and facial nerve functionality. In order to improve the clinical results, possibly reducing the complication rate, a surgical indication should be also considered for smaller KG 2 lesions of approximately 20 mm.