Different strategies in the management of thalamic space-occupying lesions

Abstract

Introduction

Thalamic space-occupying lesions (SOL) are considered challenging for microsurgical removal. Unfortunately, the pathological features of lesions occurring in the thalamic region are different with a wide variation in clinical behavior and outcome. Although microsurgery is still the gold standard in the management of these lesions through different approaches, questions remain whether surgery is feasible and safe in these patients and what are the alternatives? It is well known that stereotactic techniques may be favorable especially in cystic, small, multiple lesions and in combination with adjuvant therapy. Transventricular endoscopic approach is also an alternative technique to combine tumor biopsy and treatment of hydrocephalus.

Aim of the study

The identification of the different procedures for the management of thalamic SOL in respect to the age of the patient, the clinical condition, and the site of the lesion as well as its extent and pathology.

Patients and methods

This prospective study included 35 patients having thalamic lesions with a mean age of 27 years old who were treated with different approaches including microsurgical, stereotactic, and endoscopic approaches. The clinical outcome was assessed as the same, improved, deteriorated, or died in comparison to the initial clinical status, while the radiological control was measured as no gross residual, residual < 10% and residual > 10%. Chi-square test was used to test the association between two categorical variables.

Results

Thirty-five patients were included in this study, 20 were males and 15 were females. Eight cases were children, and 27 cases were adults. The most common clinical presentation was contralateral hemiparesis. The most common pathology was pilocytic astrocytoma. Radiological studies showed that the total thalamic type was the most common topographic variant and that 10 cases had hydrocephalus treated with CSF diversion procedures. For the definitive lesion, 2 cases underwent endoscopic biopsy and cystoventriculostomy and 18 cases had stereotactic technique in the form of biopsy, aspiration, and ommaya reservoir application, while 15 cases had microsurgery through different approaches with stereotactic technique preceding surgery in 2 of them.

Conclusion

The main factors involved in choosing the appropriate approach included nature of the lesion (solid or cystic, multiplicity), suspected pathological type, and diffusion tensor imaging. Abscesses are best treated with stereotaxy, while non-neoplastic cystic lesions (other than abscesses) related to the ventricles are best treated with endoscopy. For the remaining pathologies, maximum surgical removal is the best management. Best lesion control was provided by microsurgery.

Trial registration

ISRCTN 1380 registered 6/11/2018

Introduction

The thalamus has a unique anatomical configuration. It has three free surfaces with its ventrolateral border in contact with the subthalamic nuclei and the internal capsule. Its relation to important and vital structures hinders gross total resection and makes it hazardous and questionable regarding the increased risks of associated morbidity with poor outcomes [1, 2].

Thalamic lesions are classified into (1) unilateral thalamic tumors, originating from one thalamus with possible extension to adjacent structures; (2) thalamopeduncular tumors, arising at the junction of the thalamus and the cerebral peduncle with symmetrical supra- and infratentorial extension; and (3) bilateral thalamic tumors, originating from both thalami as opposed to tumors with contralateral extension [3].

There is a relation between the patients’ age and the pathological grade of thalamic lesions: they are usually malignant in adults with limited possibility of radical removal, while they are often benign in children and could be removed totally with better outcome [4,5,6]. Thalamic space-occupying lesions (SOL) include different pathological types as different grades of gliomas, lymphomas, metastasis, pyogenic abscesses, arteriovenous malformations, cavernomas, and thalamic neuroepithelial cysts [6,7,8,9,10].

The most common clinical presentations associated with thalamic space-occupying lesion are manifestations of increased ICP and/or motor deficits [3]. Medial or dorsal thalamic lesions protruding in the ventricular system have a greater probability of causing obstructive hydrocephalus. Presentation with sensory deficits is unusual [3, 10].

Recent imaging modalities including diffusion tensor imaging provide an important tool for the planning of operative approaches to thalamic lesions as well as decreasing the risk of postoperative morbidity [11,12,13].

The appropriate management for these lesions is still debatable with no standard treatment strategy [4, 13,14,15]. Different techniques have been discussed in the literature including endoscopic techniques in the form of biopsy or cerebrospinal fluid (CSF) diversion [16], stereotactic techniques in the form of biopsy or cyst aspiration [17], and microsurgery that could provide total or subtotal resection [3].

Microsurgery could be performed through (1) transcortical transventricular approaches whether parietal for pulvinar lesions and those extending laterally or frontal for those with anterior thalamic locations, (2) anterior interhemispheric transcallosal-transventricular approach in tumor extending from anterior to posterior in a longitudinal shape, (3) contralateral infratentorial supra-cerebellar approach used mainly for lesions arising from the pulvinar and extending in the posterior third ventricle, (4) posterior interhemispheric parasplenial approach commonly described as the preferred approach for lesions involving the medial wall of the trigone and pulvinar, and (5) transylvian transinsular approach for lateral thalamic lesions [18, 19].

Subjects and methods

This prospective study included 35 patients with thalamic lesions who underwent preoperative evaluation including patient demographics and clinical examination, and neuroimaging studies including magnetic resonance (MR) imaging prior to treatment and during the follow-up period, and in addition, most patients had undergone a preoperative head CT scan. Certain cases did MR tractography. Heterogeneity, cystic nature of the lesions, presence of calcification, contrast enhancement, and the presence of hydrocephalus were noted. Planning of the definite procedure was based on age of the patient, site of the tumor, its extent, its neuroimaging feature, expected grade of malignancy, feasibility of safe biopsy, and total resection.

The procedure applied included one or a combination of the following:

• Stereotactic biopsy using Leksell stereotactic frame

• Endoscopic third ventriculostomy using 0 lens rigid Gaab endoscope

• Endoscopic fenestration and biopsy using 0 lens rigid Gaab endoscope

• Total microsurgical excision

• Partial microsurgical excision

• Postoperative radiotherapy and chemotherapy

Postoperative evaluation includes early postoperative evaluation and after 6 months for clinical outcome and tumor control. Clinical outcome was recorded as clinical improvement (defined as partial or complete relief of symptoms), same or unchanged, deteriorated state (defined as progression of clinical symptoms), and died. Radiological control was assessed by the residual size of the lesion on postoperative images after 6 months. They were categorized as partial resection with residual (> 10%), subtotal resection (< 10%), or gross total resection with no residual tumor on postoperative imaging.

Written informed consent to participate in the study was provided by all participants.

Results

Age and sex distribution among patients (Table 1)

Table 1 Age and sex distribution among patients

Distribution of the lesion

None of the cases were bilateral; 21 lesions (60%) were located in the right thalamus while 14 lesions (40%) were located in the left thalamus (Fig. 1).

Fig. 1

Pie chart showing percentage distribution of the lesions in the thalamus

Topographic variants (Fig. 2)

• Anterior (at the level of foramen of Monro): three cases (8.5%)

• Lateral: five cases (14.3%)

• Posterior: nine cases (25.7%)

• Total (occupying the whole thalamus): 16 cases (45.8%)

• Thalamopeduncular: two cases (5.7%)

Fig. 2

Pie chart showing percentage distribution of the topographic variants

Pathology

These lesions were classified into solid, partly solid-cystic, and cystic lesions. The most common pathology was pilocytic astrocytoma (35%) followed by grades II and III gliomas (32%), GBM (15%), abscess (12%), and benign cyst (6%).

Relation of the pathology with the age

• Most common pathology below 18 years was pilocytic astrocytoma (87%).

• Most common pathology above 18 years was high-grade glioma (39%).

Clinical presentation

Most common clinical presentation was hemiparesis in 21 cases(60%), followed by manifestation of increased ICP (headache, nausea, and vomiting) in 13 cases (37%), 3 cases (8.5%) presented with hemiparathesia, 1 case (3%) showed signs of meningeal irritation signs, and 1 case (3%) presented with convulsion.

Imaging criteria (Table 2)

Table 2 Imaging criteria of different pathologies

Distribution and management of hydrocephalus

Hydrocephalus was found in 10 cases

• Five total thalamus

• Four posterior thalamus

• One anterior thalamus

Level of obstruction

• Eight cases at the third ventricle

• Two cases at the Foramen of Monro (1 case anterior thalamic and the other total thalamic).

• 1. VP shunt

• Done in seven cases VP shunt was inserted before definitive surgery because radicality was questionable with the level of obstruction at the third ventricle

• 2. VP shunt and endoscopic septostomy

• Done in two cases with the level of obstruction at the foramen of Monro

• 3. Endoscopic cystoventriculostomy and third ventriculostomy

• Done in a single case with the level of obstruction at the third ventricle

Management of the lesion

Endoscopic techniques (two cases)

Endoscopic biopsy and cystoventriculostomy

• In two cases

Stereotactic techniques (18 cases)

• A. Stereotactic biopsy (16 cases) (Fig. 3)

• B. Stereotactic aspiration (six cases).

  • Nature of aspirate: four cases were abscesses (Figs. 4 and 5)

• C. Stereotactic application of ommaya reservoir (three cases) (Fig. 6)

Fig. 3

Stereotactic CT for left thalamic pilocytic astrocytoma

Fig. 4

a: On the left MRI axial T1 with contrast showing right thalamic abscess and b on the right post stereotactic aspiration CT showing right thalamic abscess aspiration

Fig. 5

a On the left MRI axial T1 with contrast showing left thalamic cyst and b on the right post stereotactic aspiration CT showing left thalamic cyst was aspirated, c below: aspirate was pus (cyst was an abscess)

Fig. 6

a On the left stereotactic CT for aspiration and biopsy from left thalamic pilocytic astrocytoma, b: on the right CT brain post stereotactic aspiration and application of ommaya reservoir after 2 years. c below presenting follow up CT showing stationary course with no increase in the size of the lesion

Microsurgical approaches: (15 cases) (Table 3)

• 1. Transcortical transventricular (Figs. 7, 8, 9, and 10)

• 2. Posterior interhemispheric (Fig. 11)

• 3. Anterior interhemispheric (Fig. 12)

Table 3 Different microsurgical approaches

Fig. 7

a On the left coronal T2 MRI for anterior thalamic pilocytic astrocytoma and b on the right shows total removal through anterior transcortical approach (middle frontal gyrus approach)

Fig. 8

a On the left axial T1 contrast for posterior thalamic glioma and b on the right follow up CT showing removal through parietal transcortical approach

Fig. 9

a On the left MRI axial T1 contrast for left thalamic glioma and b on the right follow up CT showing removal through parietal transcortical approach

Fig. 10

a On the left MRI axial T1 contrast for left total thalamic pilocytic astrocytoma, b on the right follow up CT after 3 months showing complete removal through parietal transcortical approach, c bottom MRI axial T1 contrast done after 6 months follow up with gross total resection

Fig. 11

a On the left showing axial T1 with contrast MRI for posterior thalamic glioma and b on the right shows subtotal removal through posterior interhemispheric approach

Fig. 12

a On the left showing axial T1 MRI for total thalamic glioma and b on the right shows gross total removal through anterior interhemispheric approach

Complications of the procedure (postoperative complications)

Stereotactic cases

• Hemorrhage in a single case

• Superficial wound infection in a single case

Microsurgical cases

• Hemiparesis in the upper limb more than in the lower limb in a single case

• Dysphasia in a single case

Outcome

Clinical outcome after 6-month follow-up

Endoscopic cases: (two cases)

• One case improved clinically (50%) and the other one deteriorated (50%).

Stereotactic cases: (18 cases)

• Six cases (33%) improved clinically, 10 cases (55%) remained the same, and 2 cases (12%) deteriorated

Microsurgical cases: (15 cases)

• Eight cases (53.3%) improved clinically, three cases (20%) remained stationary in comparison to the preoperative status, and four cases deteriorated (26.6%), two of them were high-grade gliomas, two cases were low-grade glioma: patients deteriorated due to large residual

Radiological control after 6 months

Endoscopic cases: (two cases)

• One case showed no residual (50%)

• One case showed residual more than 10% (50%)

Stereotactic cases: (18 cases)

• Four cases (23%) showed no residual or residual less than 10%

• Fourteen cases (77%) showed residual more than 10%

Microsurgical cases: (15 cases)

• Ten cases (66%) showed no residual or residual less than 10%

• Five cases (33%) showed residual more than 10%

Discussion

The management of thalamic SOL should be tailored case by case. Factors involved in decision making regarding the management include the pathology and morphology of the lesion whether cystic or solid. Cystic lesions in intimate relationship to the ventricular system are managed by endoscopic fenestration, as agreed by Tirakotai and Bertalanffy, as they described the role of neuroendoscopy in cystic periventricular lesions [20]. In this study, endoscopic biopsies were done in two cases: one was a thalamic tumor that was protruding in the ventricle and the other one was a thalamic cyst. Cystic lesions not in intimate relation to the ventricular system were mainly managed by stereotactic aspiration and ommaya reservoir application. In all cystic lesions, abscesses should be excluded and if proven to be abscess by MRI diffusion the best treatment is stereotactic aspiration.

Small, solid lesions are preferentially managed by stereotaxy, which was agreed by Moshel et al. who stated that the main indications of stereotactic biopsy depended on the nature of the lesion (deep seated, multiple, extensive, small, poorly defined, inflammatory, or all of these characters together) [17]. Multiplicity of the lesion is an important factor in choosing a minimally invasive approach as stereotaxy or endoscopy.

Special pathological types as lymphomas and germ cell tumors give best results if treated by a minimally invasive approach as stereotaxy or endoscopy followed by adjuvant therapy rather than microsurgical resection [17].

In this study, stereotactic techniques were used in 18 cases. The main indications were (1) all cystic lesions not in intimate relation to the ventricle, (2) partly solid partly cystic lesions with calcification, (3) lesions showing corticospinal tracts infiltration in tractography, (4) small lesions, and (5) lastly patient’s desire for minimally invasive technique.

Out of 18 cases that where managed by stereotaxy, only two cases developed complications, with a complication rate of 11%, and the risk of intracerebral hemorrhage from stereotactic techniques was 5.5%, with no perioperative mortality. This was consistent with Air, whose complication rate was 6.7% [21].

Following the 18 stereotactic cases for 6 months, 6 cases improved (33%). The outcome depended on two important factors the pathology and the technique. The results demonstrated that the type of pathology being cystic showed statistically significant difference in relation with the improved clinical outcome in stereotactic cases as p = 0.027.

These cases had a cystic component whether low-grade cystic gliomas or abscesses. During the 6-month follow-up, no lesions showed recollection; however, this period of clinical follow-up is too short to judge the recollection and the reappearance of manifestations. Also the technique of stereotactic aspiration is related with good clinical outcome as p = 0.01.

However, two stereotactic cases (11%) deteriorated and or died during the 6-month follow-up. These two lesions were high-grade gliomas, and this may explain the cause of deterioration but cannot be statistically proven.

For radiological control of the stereotactic lesions, four cases (22%) out of 18 showed no residual or residual less than 10%. Results of this study showed that the type of pathology being cystic in nature showed statistically significant difference in relation with the gross removal of the lesion (= no residual) in stereotactic cases as p = 0.046 and that stereotactic aspiration technique showed statistical significance as regard lesion control as p = 0.014; this was also agreed by Air [21] who concluded that stereotactic aspiration is a useful management option for abscesses located in eloquent or inaccessible regions.

In large solid lesions, debulking by microsurgery is usually the best, as declared by Zhang et al. and Puget et al.; in their series, larger resection, whether it was in patients with a low- or high-grade lesions, was associated with better clinical outcome, proving that the extent of resection is an important determinant [3, 22]. In large solid lesions planned for microsurgery, MR tractography is usually indicated to assess the feasibility of microsurgery, the designed approach, and the expected morbidity, this was supported by Moshel et al. who showed the important role of tractography in choosing and planning the surgical approach through confirming the relationship between white matter fiber bundles and brain tumor in preoperative decision making [12].

In the relation between the pathology of the thalamic lesions and the patients’ age, eight cases were below 18 years of age, seven of them were low-grade glioma (87%) namely pilocytic astrocytoma which was in concordance with a study by Sweet, where it showed the highest rate of low-grade glioma to be among the pediatric population [23, 24]. This emphasizes that radical removal of all lesions in patients below 18 years of age should be attempted, as they are mostly low-grade lesions and their total removal has a more favorable outcome.

As regards the relation of improved clinical outcome and microsurgery in this study, p value = 0.41 shows no statistical significance; however, this could be explained by the short period of clinical follow-up of cases. Regarding the radiological control, there was a statistical significance between lesion control and microsurgery in this study as p value = 0.03. This was agreed by Sai Kiran et al. who concluded that radical resection results in the improvement of clinical condition as well as tumor control in majority of the patients with thalamic tumors [25].

Conclusion

The current study showed that there are different approaches for the management of thalamic lesions including endoscopic, stereotactic, and microsurgical approaches. Radiological control shows strong statistical relation with microsurgery.