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Intraosseous cavernous hemangioma: presentation of a clinical case

Abstract

Background

Cavernous hemangiomas are benign tumors that exceptionally affect the cranial bones. The first description of this type of tumor was in 1845 by Toynbee. A review of the literature reveals less than 100 published cases and a growing trend every year. Total surgical excision is the treatment of choice, and the prognosis after complete excision is excellent, with a recurrence usually rare.

Case presentation

We present the case of a 57-year-old patient with a painless tumor of the left frontal bone, of slow growth and osteolytic characteristics from the neuro-radiological point of view. The lesion was excised en bloc by craniectomy, followed by cranioplasty. The anatomopathological diagnosis was intraosseous cavernous hemangioma.

Conclusions

Despite its low frequency, the diagnosis of intraosseous cavernous hemangioma should be considered in the presence of a slow-growing cranial tumor, with solid and painless characteristics, and its osteolytic nature confirmed by radiology. The treatment of choice consists in the complete resection of the lesion.

Background

Primary intraosseous cavernous hemangiomas (PICHs) are a rare and infrequent tumor representing 0.7 to 1.0% of all bone tumors [1]. PICHs are usually found in the spine and rarely appear in the vault cranial, being 0.2% of cranial bone tumors [2]. The first description of this type of tumors was in 1845 by Toynbee. A review of the literature reveals about 100 published cases and a growing trend every year (Table 1) [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77]. These tumors are seen mostly in middle age, with a peak around the fourth decade and a male/female ratio that ranges between 3:1 and 2:1 [2].

Table 1 Review of the literature from 1845 to 2016 of the published cases of intraosseous hemangiomas

Case report

We are dealing with a 57-year-old patient, with no history of interest, referred to our Service for surgical assessment. It had presented, for 4.5 years, a small tumor in the left front region of 1.5 cm in diameter, which had slowly increased in size (Fig. 1c, d). During the examination, a mass of solid and hard consistency, painless and adhered to deep planes, was palpated under a normal-looking skin. The plain radiograph (Fig. 1a, b) and the CT (Fig. 1d) showed a left frontal intraosseous lesion with osteolytic characteristics with moderate aggressiveness. The radiological differential diagnosis included bone metastasis or plasmacytoma. The systemic studies of tumor tracking (blood count, hematological smear, tumor markers, proteinogram, and cervical-thoraco-abdominal CT) were negative. The percutaneous puncture with fine needle of the tumor was inconclusive for the diagnosis; only blood fragments were obtained. Finally, it was decided to surgically intervene the patient based on the clinical progression of the lesion, with its esthetic implications, as well as to obtain a definitive histological diagnosis. During the surgery, a bone-dependent tumor was identified, with multiple dilated vascular channels in its center, which expanded the external table. To avoid manipulation of the lesion, it was decided to include it in a piece of craniectomy with a circumferential margin of 1 cm of the seemingly healthy bone. The resulting bone defect was reconstructed by means of a cylindrical metametacrylate plasty, which was fixed to the surrounding bone with titanium miniplates. The postoperative period was uneventful. The definitive anatomopathological diagnosis was intraosseous cavernous hemangioma.

Fig. 1
figure1

Radiological images of a left frontal intraosseous lesion. a Simple X-ray of the skull, in the antero-posterior view and b in the lateral view of a radiolucent lesion (white arrows), rounded, with well-defined edges, located in the left frontal bone. c First CT cerebral with bone window performed on the patient 3 years ago. In localization of the left frontal region, a lytic bone lesion is observed that discreetly expands the diploe both in its internal and external table, with well-defined contours in its medullar region, being worse defined there could even be minimal solutions of continuity in the internal table. A poorly defined trabecular bone pattern was observed inside the lesion. The findings are compatible with a moderate aggressiveness. d In the last CT cerebral, it was appreciated how the lesion had increased in size. Produces a slight insufflation of the frontal calotte with loss of the cortex of the external table. Its behavior is of low radiological aggressiveness

Discussion

The first case of cranial cavernous hemangioma was described by Toynbee in 1845 [54]. Since then, most of the publications in the scientific literature have been presented in a single clinical case format, with the exception of two reviews of extensive casuistry that constitute the main references on this entity [22]. PICHs of the skull are rare benign vascular tumors, accounting for about 0.2% of all tumors and 10% of benign tumors of the skull [59]. They occur most frequently in the spine and rarely in the skull. Of the 93 cases of cranial PICH reported in the literature from 1845 to 2015, 44.1% were located in the frontal bone, 12.9% in the temporal bone, 11.8% occurred in the occipital bone, 12, 9% in the parietal, and 5.4% in the cranial fossa; fewer cases have been reported in sphenoid, zygomatic, ethmoid, clivus, and orbital, etc. [37]. In the review carried out by Wyke, this distribution is supported [19].

They are usually unique lesions, although cases of multiple cranial cavernomas have been described [28]. They usually have a size at the time of diagnosis that ranges between 15 and 25 mm, although lesions of up to 8 cm diameter have been described [78]. Its origin is in the vessels of the diploic space, and their blood supplies are branches of the external carotid artery. The middle and superficial temporal arteries are the main sources of blood supply. Within the lesion, the capillaries are widely dilated and separated by fibrous tissue [77]. Its pathogenesis remains unknown. It was believed that it could be congenital, but this has not yet been proven. A previous trauma could also be an important etiology to consider [77]. The typical presentation is given by the presence of a hard, painless mass that slowly increases in size under an overlying intact skin. Sometimes they are associated with headache, which can be of high intensity when the hemangioma expands [79]. The most common clinical feature is a solid tumor in the skull, painful or painless.

The cranial CT with a bone window is the diagnostic modality of choice, since it surpasses the sensitivity of simple radiography and allows bone to be defined in a superior way to MRI, giving a detailed image of the cortical and trabecular bone. Although the appearance in the CT can vary, the characteristic image consists of a lytic lesion, oval or rounded, expansive, and well delimited, with trabeculae that radiate from a common center in its interior in the tangential cuts, giving sometimes an appearance of honeycombing in the axial cuts [21]. It frequently invades and expands the external table, respecting the periosteum. Usually no signs of reactive hyperostosis are identified at their margins [22]. The cortex can undergo a great expansion leaving a thin bone layer, but in almost all cases, the periosteum remains intact and usually without reactive sclerosis at the margins. The angiography of these lesions, typically the largest, demonstrates a hypervascular lesion, but without drainage veins. Preoperative embolization may be useful in some cases [80]. The differential diagnosis includes other slow-growing, expanding bone lesions, such as osteoma, aneurysmal bone cyst, giant cell tumor, and multiple myeloma [81]. The radiological characteristics that help the differential diagnosis are shown in Table 2.

Table 2 Differential diagnosis of skull vault lesions

The natural history of these pathologies has not yet been described. Considering that osseous cavernous hemangiomas grow progressively, without spontaneous involution, their surgical treatment is usually recommended for several reasons: progression of the painful clinic, cosmetic implications, and, although with low frequency, avoidance of complications such as hemorrhages or nerve damage cranial, depending on the location of the lesion [22]. In 1923, Cushing designed the one that represents the treatment of choice of cranial cavernous hemangiomas to the present day: en bloc resection of the lesion, including a circumferential margin of the healthy bone [11]. On the other hand, the possibility of recurrence is avoided by including a margin of safety [77]. Most authors recommend total surgical excision to treat the mass effect and neurological compromise, to improve an esthetic deformity, and to obtain a definitive diagnosis [11]. The surgical approach becomes more difficult for those with extension to the base of the skull. Radiotherapy should be reserved for those lesions that are considered unresectable or in the case of recurrent tumors. This therapeutic modality stops tumor growth and reduces vascularization, but does not modify the size of the lesion and carries the risk of malignancy or the appearance of de novo malignancies [39].

Conclusions

Cranial cavernous hemangiomas are bony tumors of nature, which, in the absence of typical radiological features, are usually surgically treated under suspicion of another type of bone neoplasm. The treatment of choice is a complete resection by craniectomy, including healthy bone margins of safety, with good prognosis and little recurrence. In the presence of subtotal resections or progression, radiotherapy could be a valid option.

Abbreviations

CT:

Computed tomography

DWI:

Diffusion-weighted imaging

MRI:

Magnetic resonance imaging

PICHs:

Primary intraosseous cavernous hemangiomas

T1WI:

T1-weighted imaging

T2WI:

T2-weighted imaging

References

  1. 1.

    Park BH, Hwang E, Kim CH. Primary intraosseous hemangioma in the frontal bone. Arch Plast Surg. 2013;40:283–5.

    Article  Google Scholar 

  2. 2.

    Peterson DL, Murk SE, Story JL. Multifocal cavernous hemangioma of the skull: report of a case and review of the literature. Neurosurgery. 1992;30:778–81.

    CAS  PubMed  Google Scholar 

  3. 3.

    Pilcher LS. Venous tumour of the diploe: Trans Am Surg Assoc. 1894;2:283–5.

    Google Scholar 

  4. 4.

    Wyke DB. Primary hemangioma of the skull: a rare cranial tumor. Am J Roentgenol. 1949;61:302–16.

    CAS  Google Scholar 

  5. 5.

    Gupta SD, Tiwari IN, Pasupathy NK. Cavernous haemangioma of the frontal bone: case report. Br J Surg. 1975;62:330–2.

    CAS  Article  Google Scholar 

  6. 6.

    McIntyre NG, Brebner DM, Gluckman J. The cavernous haemangioma of the frontal bone. A case report. S Afr Med J. 1977;52:537–8.

    CAS  PubMed  Google Scholar 

  7. 7.

    Gross HJ, Roth AM. Intraosseous hemangioma of the orbital roof. Am J Ophthalmol. 1978;86:565–9.

    CAS  Article  Google Scholar 

  8. 8.

    Fouad HA, Khalifa MC. Haemangioma of the frontal bone. J Laryngol Otol. 1979;93:513–8.

    CAS  Article  Google Scholar 

  9. 9.

    Shinno K, Nakagawa Y, Matsumoto K, Ii K. Cavernous hemangioma of the frontal bone. No Shinkei Geka. 1986;14:1231–5.

    CAS  PubMed  Google Scholar 

  10. 10.

    Hook SR, Font RL, McCrary JA, Harper RL. Intraosseous capillary hemangioma of the frontal bone. Am J Ophthalmol. 1987;103:824–7.

    CAS  Article  Google Scholar 

  11. 11.

    Zucker JJ, Levine MR, Chu A. Primary intraosseous hemangioma of the orbit: report of a case and review of the literature. Ophtalmic Plast Reconstr Surg. 1989;5:247–55.

    CAS  Article  Google Scholar 

  12. 12.

    Hoffmann DF, Israel J. Intraosseous frontal hemangioma. Head Neck. 1990;12:160–3.

    CAS  Article  Google Scholar 

  13. 13.

    Hornig GW, Beatty RM. Osteolytic skull lesions secondary to trauma. Report of two cases. J Neurosurg. 1990;72:506–8.

    CAS  PubMed  Google Scholar 

  14. 14.

    Sinnreich Z, Kremer S, Sade J, Bernheim J. Cavernous hemangioma of the frontal bone. ORL J Otorhinolaryngol Relat Spec. 1990;52:269–72.

    CAS  Article  Google Scholar 

  15. 15.

    Aurora A, Krishnan MM, Bahadur R, Vidyasagar JV, Ratnakar C. Cavernous hemangioma of the frontal bone: a case report. Indian J Ophthalmol. 1991;39:76–7.

    CAS  PubMed  Google Scholar 

  16. 16.

    Faerber TH, Hiatt WR. Hemangioma of the frontal bone: review of the literature and report of a case. J Oral Maxillofac Surg. 1991;49:1018–22.

    CAS  Article  Google Scholar 

  17. 17.

    Relf SJ, Bartley GB, Unni KK. Primary orbital intraosseous hemangioma. Ophthalmology. 1991;98:541–7.

    CAS  Article  Google Scholar 

  18. 18.

    Cervoni L, Artico M, Delfini R. Intraosseous cavernous hemangioma of the skull. Neurosurg Rev. 1995;18:61–4.

    CAS  Article  Google Scholar 

  19. 19.

    Pastore FS, De Caro GM, Faiola A, Mauriello A, Giuffre R. Cavernous hemangioma of the parietal bone. Case report and review of the literature. Neurochirurgie. 1999;45:312–5.

    CAS  PubMed  Google Scholar 

  20. 20.

    Sharma RR, Pawar SJ, Lad SD, Netalkar AS, Musa MM. Frontal intraosseous cryptic hemangioma presenting with supraorbital neuralgia. Clin Neurol Neurosurg. 1999;101:215–9.

    CAS  Article  Google Scholar 

  21. 21.

    Suzuki Y, Ikeda H, Mutsamoto K. Neuroradiological features of intraosseous cavernous hemangioma. Neurol Med Chir (Tokyo). 2001;41:279–82.

    CAS  Article  Google Scholar 

  22. 22.

    Heckl S, Aschoff A, Kunze S. Cavernomas of the skull: review of the literature 1975-2000. Neurosurg Rev. 2002;25:56–62.

    Article  Google Scholar 

  23. 23.

    Pottelbergh R, Calenbergh F, Goffin J, Sciot R, Plets C. Tijdschrift voor Geneeskunde. 2004;60(2):126–31.

    Article  Google Scholar 

  24. 24.

    Politi M, Romeike BF, Papanagiotou P, Nabhan A, Struffert T, Feiden W, et al. Intraosseous hemangioma of the skull with dural tail sign: radiologic features with pathologic correlation. AJNR Am J Neuroradiol. 2005;26:2049–52.

    PubMed  Google Scholar 

  25. 25.

    Cheng NC, Lai DM, Hsie MH, Liao SL, Chen YB. Intraosseous hemangiomas of the facial bone. Plast Reconstr Surg. 2006;117:2366–72.

    CAS  Article  Google Scholar 

  26. 26.

    Buhl R, Barth H, Dörner L, Nabavi A, Rohr A, Mehdorn HM. De novo development of intraosseous cavernous hemangioma. J Clin Neurosci. 2007;14:289–92.

    Article  Google Scholar 

  27. 27.

    Nasser K, Hayashi N, Kurosaki K, Hasegawa S, Kurimoto M, Mohammed A, et al. Intraosseous cavernous hemangioma of the frontal bone. Neurol Med Chir (Tokyo). 2007;47:506–8.

    Article  Google Scholar 

  28. 28.

    Naama O, Gazzaz M, Akhaddar A, Belhachmi A, Asri A. El- mostarchid B, et al. Cavernous hemangioma of the skull: 3 case reports. Surg Neurol. 2008;70:654–9.

    Article  Google Scholar 

  29. 29.

    Sasagawa Y, Akai T, Yamamoto K, Masuoka T, Itou S, Oohashi M, et al. Multiple cavernous hemangiomas of the skull associated with hepatic lesions. Case report. Neurol Med Chir (Tokyo). 2009;49:162–6.

    Article  Google Scholar 

  30. 30.

    Carrasco-Moro R, García-Navarrete E, Navas-García M. M. Adrados de Llano y R. García de Sola Carrasco. Cavernous haemangioma of the skull. Neurocirugia (Astur). 2009;20(6):559–62.

    CAS  Article  Google Scholar 

  31. 31.

    Haeren RHL, Dings J, Hoeberigs MC, Riedl RG, Rijkers K. Posttraumatic skull hemangioma. Case report. Journal of Neurosurgery. 2012;6:1082–8.

    Article  Google Scholar 

  32. 32.

    Xu P, Lan S, Liang Y, Xiao Q. Multiple cavernous hemangiomas of the skull with dural tail sign: a case report and literatura review. BMC Neurol. 2013;13:155.

    Article  Google Scholar 

  33. 33.

    Uemura K, Takahashi S, Sonobe M, Oyama K, Akai T, Sugita K. Intradiploic haemagioma o associated with epidural haematoma. Neuroradiology. 2014;38:456–7.

    Article  Google Scholar 

  34. 34.

    Murrone D, De Paulis D, Millimaggi DF, Del Maestro M, Galzio RJ. Cavernous hemangioma of the frontal bone: a case report. J Med Case Rep. 2014;8:121.

    Article  Google Scholar 

  35. 35.

    Chun KA, Kong E, Cho I. An Incidental Finding of Skull Hemangioma During 18F-FP CIT Brain PET/CT. Clin Nucl Med. 2015;40(10):e488–9. https://doi.org/10.1097/RLU.0000000000000907.

    Article  Google Scholar 

  36. 36.

    Hsiao IH, Cho DY, Liu CL. Multifocal osteolytic lesions of the skull: a primary cavernous hemangioma mimicking a neoplastic invasive lesion. Biomedicine (Taipei). 2015;5:12.

    Article  Google Scholar 

  37. 37.

    Y Yang, J Guan, Ma W, et al. Primary Intraosseous Cavernous Hemangioma in the Skull. Medicine (Baltimore). 2016. https://doi.org/10.1097/MD.0000000000003069.

    Article  Google Scholar 

  38. 38.

    Sargent EN, Reilly EB, Posnikoff J. Primary hemagioma of the skull. Case report of an unusual tumor. AM J Roentgenol Radium Ther Nucl Med. 1965;95:874–9.

    CAS  Article  Google Scholar 

  39. 39.

    Mangham CA, Carberry JN, Brackmann DE. Management of intratemporal vascular tumors. Laryngoscope. 1981;91:867–6.

    CAS  Article  Google Scholar 

  40. 40.

    Glasscock MEIII, Smith PG, Schwaber MK, Nissen AJ. Clinical aspects of osseous hemangiomas of the skull base. Laryngoscope. 1984;94:869–73.

    Article  Google Scholar 

  41. 41.

    Suss RA, Kumar AJ, Dorfman HD, Miller NR, Rosenbaum AE. Capillary hemangioma of the sphenoid bone. Skeletal Radiol. 1984;11:102–7.

    CAS  Article  Google Scholar 

  42. 42.

    Mazzoni A, Pareschi R, Calabrese V. Intratemporal vascular tumours. J Laryngol Otol. 1988;102:353–6.

    CAS  Article  Google Scholar 

  43. 43.

    Buchanan DS, Fagan PA, Turner J. Cavernous hemangioma of the temporal bone. J Laryngol Otol. 1992;106:1086–8.

    CAS  Article  Google Scholar 

  44. 44.

    Fierek O, Laskawi R, Kunze E. Large intraosseous hemangioma of the temporal bone in a child. Ann Otol Rhinol Laryngol. 2004;113:394–8.

    Article  Google Scholar 

  45. 45.

    Silva RD, da Silva Cavalcante JE, Miranda EQ, Lopes DF, Souto LR. Giant hemangioma presenting as a scalp mass leading to a craniofacial deformity. J Maxillofac Oral Surg. 2013;12(2):218–23. https://doi.org/10.1007/s12663-011-0218-9. Epub 2011 Apr 20.

    Article  PubMed  Google Scholar 

  46. 46.

    Yang M, Yan JJ. Long term surgical outcomes of orbital cavernous haemangiomas (low-flow venous malformations) as performed in a tertiary eye hospital in China. Craniomaxillofac Surg. 2014 Oct;42(7):1491–6.

    Article  Google Scholar 

  47. 47.

    Yetişer S, Yapıcıer O. Primary intraoseous hemangioma of temporal bone. Kulak Burun Bogaz Ihtis Derg. 2014;24(2):100–4. https://doi.org/10.5606/kbbihtisas.2014.45452

    Article  PubMed  Google Scholar 

  48. 48.

    Corr P. Multiple calvarial haemangiomas. Australas Radiol. 2000;44:118–20.

    CAS  Article  Google Scholar 

  49. 49.

    García-Marín V, Ravina J, Trujillo E, González-Feria L. Symptomatic cavernous hemangioma of the occipital condyle treated with methacrylate embolization. Surg Neurol. 2001;56:301–3.

    Article  Google Scholar 

  50. 50.

    Khanam H, Lipper MH, Wolff CL, Lopes MB. Calvarial hemangiomas: report of two cases and review of the literature. Surg Neurol. 2001;55:63–7.

    CAS  Article  Google Scholar 

  51. 51.

    Gibson SE, Prayson RA. Primary skull lesions in the pediatric population: a 25-year experience. Arch Pathol Lab Med. 2007;131:761–6.

    PubMed  Google Scholar 

  52. 52.

    Reis BL, Carvalho GT, de Sousa AA, de Freitas WB, Castro Santiago Brandão RA. Primary hemangioma of the skull Arq. Neuro-Psiquiatr. 2008;66:3.

    Google Scholar 

  53. 53.

    Nair P, Srivastava AK, Kumar R, Jain K, Sahu RN, Vij M, Jain M. Giant primary intraosseous calvarial hemangioma of the occipital bone. Neurol India. 2011;59(5):775–6. https://doi.org/10.4103/0028-3886.86568.

    Article  PubMed  Google Scholar 

  54. 54.

    Toynbee J. An account of two vascular tumors developed in the substance of bone. Lancet. 1845;2:676.

    Google Scholar 

  55. 55.

    Kumar S, Gupta S, Puri V, Mehndiratta MM, Malhotra V. Intradiploic hemangioma of skull bone. Indian Pediatr. 1993;30:399–401.

    CAS  PubMed  Google Scholar 

  56. 56.

    Yoshida D, Sugisaki Y, Shimura T, Teramoto A. Cavernous hemangioma of the skull in a neonate. Childs Nerv Syst. 1999;15:351–3.

    CAS  Article  Google Scholar 

  57. 57.

    Ajja A, Oukacha N, Gazzaz M, Akhaddar A, Elmostarchid B, Kadiri B, et al. Cavernous hemangioma of the parietal bone. A case report. J Neurosurg Sci. 2005;49:159–62.

    CAS  PubMed  Google Scholar 

  58. 58.

    Paradowski B, Zub W, Sasiadek M, et al. Intraosseous hemangioma in parietal bone. Neurology. 2007;68:44.

    CAS  Article  Google Scholar 

  59. 59.

    Rumana M, Khursheed N, Farhat M, et al. Congenital intraosseous cavernous hemangioma of the skull: an unusual case. Pediatr Neurosurg. 2013;49:229–31.

    Article  Google Scholar 

  60. 60.

    Atci IB, Albayrak S, Yilmaz N, et al. Cavernous hemangioma of the parietal bone. Am J Case Rep. 2013;14:401–4.

    Article  Google Scholar 

  61. 61.

    Kilani M, Darmoul M, Hammedi F, et al. Cavernous hemangioma of the skull and meningioma: association or coincidence? Case Rep Neurol Med. 2015:716–837.

  62. 62.

    Sarmast AH, Shafi Y, Kirmani AR, Bhat AR. A rare case of parietal bone hemangioma. J Neurosci Rural Pract. 2016;7(3):456–7. https://doi.org/10.4103/0976-3147.181458.

    Article  PubMed  PubMed Central  Google Scholar 

  63. 63.

    Brichacek M, Naeem A, Filler G, Hammond R, Yazdani A, Ranger A. Congenital Calvarial Hemangioma. J Craniofac Surg. 2018 May 8. https://doi.org/10.1097/SCS.0000000000004613.

    Article  Google Scholar 

  64. 64.

    Jackson CG, Glasscock MEIII, Hughes G, Sismanis A. Facial paralysis of neoplastic origin: diagnosis and management. Laryngoscope. 1980;90:1581–95.

    CAS  Article  Google Scholar 

  65. 65.

    Bottrill I, Poe DS. Diagnosis imaging quiz case 2. Arch Otolaryngol. 1995;121:348–50.

    CAS  Google Scholar 

  66. 66.

    Chatterhi P, Verma SM, Mathur JS. Haemangioma of the frontal bone. Journal of Laryngology and Otology. 1969;83:917.

    Article  Google Scholar 

  67. 67.

    Schofield AL. Primary haemangioma of the malar bone. Br. J. Plast. Surg. 1950;3:136–8.

    CAS  Article  Google Scholar 

  68. 68.

    Dickins J. Cavernous hemangioma of the sphenoid wing. Arch Otolaryngol. 1978;104:58–60.

    Article  Google Scholar 

  69. 69.

    Inoue A, Yamada K, Kishida K, Nakai O. Calvarial hemangioma. Report of two cases and study of 62 cases from the literature (author's transl). Neurol Med Chir (Tokyo). 1982;22:147–53.

    CAS  Article  Google Scholar 

  70. 70.

    Tashiro T, Inoue Y, Nemoto Y, Shakudo M, Mochizuki K, Katsuyama J, et al. Cavernous hemangioma of the clivus: case report and review of the literature. AJNR Am J Neuroradiol. 1991;12:1193–4.

    CAS  PubMed  Google Scholar 

  71. 71.

    Slaba SG, Karam RH, Nehme JI, Nohra GK, Hachem KS, Salloum JW. Intraosseous orbitosphenoidal cavernous angioma. Case report. J Neurosurg. 1999;91:1034–6.

    CAS  PubMed  Google Scholar 

  72. 72.

    Moore SL, Chun JK, Mitre SA, Som PM. Intraosseous hemangioma of the zygoma: CT and MR findings. AJNR Am J Neuroradiol. 2001;22:1383–5.

    CAS  PubMed  Google Scholar 

  73. 73.

    Liu JK, Burger PC, Harnsberger HR, Couldwell WT. Primary intraosseous skull base cavernous hemangioma: case report. Skull Base. 2003;13:219–28.

    Article  Google Scholar 

  74. 74.

    Jeong WJ, Rhee CS. Primary intraosseous orbital hemangioma of the lacrimal bone. Jpn J Ophthalmol. 2006 Mar-Apr;50(2):189–90.

    Article  Google Scholar 

  75. 75.

    Salunke P, Sinha R, Khandelwal NK, et al. Primary intraosseus cavernous hemangioma of the skull base. Br J Neurosurg 2010; 24:84–5.

    Article  Google Scholar 

  76. 76.

    Moravan MJ, Petraglia AL, Almast J, et al. Intraosseous hemangiomas of the clivus: a case report and review of the literature. J Neurosurg Sci. 2012;56:255–9.

    CAS  PubMed  Google Scholar 

  77. 77.

    Yu J, Li Y, Duan X. Posttraumatic cavernous hemangioma of the skull. J Craniofac Surg. 2017;25:e48–51.

    Article  Google Scholar 

  78. 78.

    Hernández-Borroto CE, Amado-Donestévez A, Vaquer-Fernández JE, Medrano-Plana Y, Ruíz-Martín M. Hemangioma cavernoso gigante de la bóveda craneal. Rev Neurol. 2004;38:799–800.

    PubMed  Google Scholar 

  79. 79.

    Bucy PC, Capp CS. Primary hemangioma of bone with special reference to roentgenologic diagnosis. AJR Am J Roentgenol. 1930;23:1–33.

    Google Scholar 

  80. 80.

    Lobato RD, Lamas E, Amor T, Rivas JJ. Primary calvarial hemangioma: angiographic study. Surg Neurol. 1978;10:389–94.

    CAS  PubMed  Google Scholar 

  81. 81.

    Patnaik A, Mishra SS, Mishra S, et al. Intradiploic ossified giant cavernous hemangioma of skull with a dural tail sign mimicking primary calvarial meningioma. Neurol India. 2012;60:250–2.

    Article  Google Scholar 

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The individual contributions of authors to the manuscript are the following: AAS has made the elaboration of the manuscript, the description of the clinical case, the review of the literature and the surgery of the presented case. NFP has made the elaboration of the images and the table. MPS has made the revision of the manuscript. All authors read and approved the final manuscript.

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Sáenz, A.A., Porto, N.F. & Sánchez, M.P. Intraosseous cavernous hemangioma: presentation of a clinical case. Egypt J Neurosurg 33, 22 (2018). https://doi.org/10.1186/s41984-018-0018-3

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Keywords

  • Skull base
  • Craniectomy
  • Intraosseous cavernous hemangioma
  • Osteolithic
  • Benign tumor