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Egyptian Journal of Neurosurgery

Table 1 Common genetic alteration in meningiomas [42,43,44,45,46,47,48,49,50,51,52,53,54]

From: Review of meningioma diagnosis and management

Meningioma location

Meningioma subtype

Common genetic alterations

Convexity Meningioma

Fibrous

NF2, SMARCB1, TERT, CDKN2A

Transitional

NF2, SMARCB1, TERT, CDKN2A

Skull Base Meningioma

Meningothelial

AKT1, SMO, POLR2A, PIK3CA

Microcystic

AKT1, KLF4, TRAF7, SMO, POLR2A, PIK3CA

Secretory

KLF4, TRAF7

Spinal Cord Meningioma

Clear Cell

SMARCE1

Rhabdoid

BAP1

  1. AKT1 AKT serine/threonine kinase 1, SMO smoothened, frizzled class receptor, POLR2A RNA polymerase II subunit A, PIK3CA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha, KLF4 Krüppel-like factor 4, TRAF7 TNF Receptor Associated Factor 7, BAP1 BRCA1 Associated Protein 1
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