Table 1 Common neurodegenerative diseases and characteristic proteins
Disease | Microscopic lesion | Location | Aggregated protein |
|---|---|---|---|
Alzheimer's disease | Amyloid plaque | Extracellular | Amyloid-β |
Neurofibrillary tangle | Intracytoplasmic (neurons) | Tau | |
Lewy bodies (in Lewy body variant) | Intracytoplasmic (neurons) | α-synuclein | |
Amyotrophic lateral sclerosis | Hyaline inclusions | Intracytoplasmic (neurons) | Superoxide dismutase 1 |
Parkinson's disease | Lewy bodies | Intracytoplasmic (neurons) | α-synuclein |