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Table 1 Case reports of clivus defects with the complication of meningitis in adults

From: Clival defect in the pathogenesis of recurrent meningitis: a case report and literature review

Reference/year

Age/gender

Anatomical defect

Cause

Microorganism isolated in CSF

Surgical treatment

Recurrent meningitis

[11] / 1995

53/F

Bone defect in the superior third of the clivus

S-CSF-L

Unknown

EET

No

[11] / 1995

43/M

3-mm bone defect in the clivus

S-CSF-L

N. meningitidis

EET

No

[13] / 2007

36/F

Small bone defect of the clivus

S-CSF-L/Marfan syndrome

Unknown

EET

No

[12] / 2008

50/M

The mid-clival bony defect

S-CSF-L

Unknown

EET

No

[8] / 2013

69/F

Clival erosion and trabecular thinning

Periodontitis (osteomyelitis)

G. haemolysans

Dental procedures

Yes

[5] / 2015

60/F

16 × 9 × 4 mm bone defect within the posterior clival framework

S-CSF-L

Unknown

EET

Yes

[10] / 2017

38/M

3 × 4 mm circular bone defect in the middle of the clivus

Trauma (clivus fracture)

S. pneumoniae

EET

No

[7] / 2017

64/F

Clival defect with CSF leak into the sphenoid sinus

S-CSF-L

Unknown

EET

Yes

[9] / 2017

55/F

Midline clival defect

S-CSF-L

Unknown

SRTR

Yes

[6] / 2017

52/F

2 mm defect in the superior third of the clivus

S-CSF-L

H. influenzae

EET

No

[6] / 2017

69/M

4 mm defect in the posterior wall of the clivus

S-CSF-L

Unknown

EET

No

  1. F female, M male, CSF cerebrospinal fluid, S. aureus Staphylococcus aureus, S. pneumoniae Streptococcus pneumoniae, G.haemolysans Gemella haemolysans, H. influenzae Haemophilus influenzae, N. Meningitidis Neisseria meningitidis, S-CSF-L spontaneous CSF leakage, EET endoscopic endonasal transsphenoidal surgery, SRTR sublabial rhinoseptal transsphenoidal repair