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Table 1 Case reports of clivus defects with the complication of meningitis in adults

From: Clival defect in the pathogenesis of recurrent meningitis: a case report and literature review

Reference/yearAge/genderAnatomical defectCauseMicroorganism isolated in CSFSurgical treatmentRecurrent meningitis
[11] / 199553/FBone defect in the superior third of the clivusS-CSF-LUnknownEETNo
[11] / 199543/M3-mm bone defect in the clivusS-CSF-LN. meningitidisEETNo
[13] / 200736/FSmall bone defect of the clivusS-CSF-L/Marfan syndromeUnknownEETNo
[12] / 200850/MThe mid-clival bony defectS-CSF-LUnknownEETNo
[8] / 201369/FClival erosion and trabecular thinningPeriodontitis (osteomyelitis)G. haemolysansDental proceduresYes
[5] / 201560/F16 × 9 × 4 mm bone defect within the posterior clival frameworkS-CSF-LUnknownEETYes
[10] / 201738/M3 × 4 mm circular bone defect in the middle of the clivusTrauma (clivus fracture)S. pneumoniaeEETNo
[7] / 201764/FClival defect with CSF leak into the sphenoid sinusS-CSF-LUnknownEETYes
[9] / 201755/FMidline clival defectS-CSF-LUnknownSRTRYes
[6] / 201752/F2 mm defect in the superior third of the clivusS-CSF-LH. influenzaeEETNo
[6] / 201769/M4 mm defect in the posterior wall of the clivusS-CSF-LUnknownEETNo
  1. F female, M male, CSF cerebrospinal fluid, S. aureus Staphylococcus aureus, S. pneumoniae Streptococcus pneumoniae, G.haemolysans Gemella haemolysans, H. influenzae Haemophilus influenzae, N. Meningitidis Neisseria meningitidis, S-CSF-L spontaneous CSF leakage, EET endoscopic endonasal transsphenoidal surgery, SRTR sublabial rhinoseptal transsphenoidal repair