| |
Propofol group (n = 20)
|
DEX group (n = 20)
|
Mixed group (n = 20)
|
p value
|
|---|
|
ICP
|
|
Baseline
|
15.4 ± 3.4
|
15.7 ± 2.9
|
15.8 ± 2.6
|
0.931
|
|
After 2 h
|
14.7 ± 2.9
|
14.4 ± 2.8
|
14.1 ± 2.3
|
0.787
|
|
After 4 h
|
13.4 ± 2.1
|
13.7 ± 3
|
13.1 ± 1.9
|
0.703
|
|
After 8 h
|
13 ± 2.6
|
12.6 ± 3.5
|
12.1 ± 2.7
|
0.673
|
|
After 12 h
|
12.3 ± 3.4
|
11.9 ± 4.2
|
11.5 ± 3.9
|
0.831
|
|
After 24 h
|
11.8 ± 4.5
|
11.1 ± 5.5
|
10.8 ± 5
|
0.811
|
|
After 36 h
|
12 ± 3.5
|
11.6 ± 4.4
|
11.2 ± 3.9
|
0.797
|
|
After 48 h
|
11.8 ± 4
|
11.2 ± 4.8
|
11 ± 4.5
|
0.842
|
|
CPP
|
|
Baseline
|
86 ± 5.54
|
86.85 ± 6.25
|
87.3 ± 5.41
|
0.769
|
|
After 2 h
|
89.05 ± 4.85
|
90.3 ± 5.65
|
90.75 ± 6.93
|
0.640
|
|
After 4 h
|
89.35 ± 4.74
|
89.15 ± 6.16
|
90.95 ± 6.13
|
0.555
|
|
After 8 h
|
89.05 ± 6.92
|
89.1 ± 7.61
|
91.35 ± 6.93
|
0.514
|
|
After 12 h
|
89.55 ± 5.28
|
91.1 ± 5.56
|
90.8 ± 7
|
0.688
|
|
After 24 h
|
88.75 ± 7.74
|
90.6 ± 6.2
|
91.45 ± 7.73
|
0.489
|
|
After 36 h
|
88.1 ± 7.59
|
88.65 ± 6.44
|
90.1 ± 9.36
|
0.711
|
|
After 48 h
|
87.65 ± 9.73
|
88.8 ± 7.61
|
90.3 ± 10.15
|
0.663
|
|
Intracranial pressure excursions, number of patients (percentage)
|
6 (30%)
|
7 (35%)
|
5 (25%)
|
0.839
|
|
Cerebral perfusion pressure excursion, number of patients (percentages)
|
7 (35%)
|
5 (25%)
|
2 (10%)
|
0.192
|
- ICP excursions > 20 mmHg. CPP excursion < 50 mmHg
